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Anti-inflammatory eye drop enhance the effects of SLT

“Anti-inflammatory eye drop enhance the effects of SLT” American Academy of Ophthalmology reported:

While the ultimate objective of selective laser trabeculoplasty( SLT) is reduction in glocoma post-op drop regimen in majority of patients, prescribing topical steroid and non-steroid anti-inflammatory medications for a short period of time may help patients and physicians achieve that aim.

In November 2019, a study was published in Ophthalmology Journal in which the aim of investigators was to examine whether short-term use of steroid and non-steroidal al anti- inflammatory drug( NSAIDs)can enhance the efficacy of selective laser trabeculoplasty. The primary and secondary outcomes of study quite impressive.

Groth et al’s double masked, randomized, placebo controlled, dual centered multi-surgeon trial demonstrated that in comparison with placebo( saline tears), either use of steroidal (prednisolone 1%) or non- steroidal (Ketorolac 0.5 %) anti-inflammatory medications can equally efficious in IOP reduction at 6 and 12 weeks, with statistically significant different by week 12( P=0.02). Increasingly, patient reported pain and detectable anterior chamber inflammation were also assessed and no significant differences were noted among the treatment arms.

“Short-term postoperative use of NSAID or steroid drops may improve IOP reduction after SLT,” the investigators conclude, even though they mentioned long-term follow up studies are warranted. In further studies, patient compliance with treatment, as a major component that effective on the outcomes, also well deserved to be addressed, indeed.

Ref: 1-Groth SL et al. Ophthalmology. 2019 Nov;126(11):1511-1516.

2- https://www.aao.org/editors-choice/anti-inflammatory-eye-drops-enhance-effects-of-sel